A total of 9277 volunteer unrelated donors from the CBMDR were included in the dataset (data extracted on 01-12-2018). The donors were recruited and originate from 5 different regions of Croatia (1532 from Dalmatia, 865 from Istria & Primorje, 1021 from Central Croatia, 1877 from East Croatia, and 1049 from North Croatia) as well as from Zagreb (N = 2933), as illustrated by Figure 1. The number of samples chosen for each region correlates with its population size and represents 0.2% of the number of inhabitants for a specific region. The number of towns included for each region is as follows: 11 from Dalmatia, 8 from Istria & Primorje, 10 from Central Croatia, 9 from East Croatia, and 8 from North Croatia. Donors from the same region were then selected based on their residence in different towns situated in a given region, in such a way that all towns were adequately represented. Finally, individuals residing in the same town and carrying the same surname were excluded from the sample. The regions do not represent official Croatian counties, but rather a geographical division of Croatia. One possible disadvantage of the sample selection method used in this study is the potential gene flow due to population migrations, which regularly occur in Croatia in the direction of a regional centre of each region. For that reason, the capital city of Croatia, Zagreb, was excluded from the sample of the Central Croatia region since constant migration to Zagreb occurs from all Croatian regions. For the same reason, the sample including subjects residing in Zagreb was chosen as a sample representative of the Croatian population in general. The study was approved by the Ethics Committee of the University Hospital Zagreb, and it was performed in line with the Helsinki Declaration.

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