As scoping reviews do not formally synthesise the evidence, this review will provide a descriptive summary of the evidence and map this summary against the objectives of the review. For example, we will identify evidence on individual antioxidants with regard to the questions of interest from each review, indicating the underlying populations (types and stages of cancer, chemotherapeutic regimens) the evidence is sourced from, and the AMSTAR-2 rating of the reviews providing this information. Results will be presented in tables and charts, with frequencies calculated for data elements when appropriate (eg, the number of reviews on a particular antioxidant). We will conclude by discussing whether we believe there is reliable systematic review evidence on the potential benefits and risks of antioxidant supplements during chemotherapy and suggesting potential avenues for further research.

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