After a short registration procedure that takes place during their first visit to the web-based app, the HCPs can continuously interact with it throughout the duration of the study. HCPs are given a short in-app training session.

During the main usage of the MyPal web-based app, the HCPs can access symptom related data being stored in the system backend which had been collected by (1) the MyPal Child app and (2) the MyPal Carer app. HCPs are authorised to solely access the data of the patients of their associated clinical centre. The individual data of participating patients are reviewed by the associated HCP at least once every 72 hours to check for new entries. The data review and any action related to this are recorded through the web interface. The functionalities of the MyPal web-based app are outlined in table 4. All of them can be accessed by the HCP at any time. In addition, the HCP can use the MyPal Carer app in order to complete questionnaires as a proxy for one of their patients.

The functionalities of the MyPal web-based app offered to the HCPs

Symptoms reported by study participants can be visualised in the MyPal web-based app for HCPs to be reviewed according to adjustable settings.

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