Consenting participants that pass the baseline CBB testing (CBB ≥80) will be randomised (1:1) to receive either postoperative sedation with DEX infusion for 24 hours after surgery in the ICU or sedation per institutional practice. All other aspects of pre/intra/postoperative care will be in accordance with standard institutional practice at the discretion of the clinical team including specific induction/maintenance anaesthetic drugs, surgical care and postoperative care to reduce heterogeneity between study groups and increase generalisability. In addition to the primary and secondary outcome measures, the research team will record demographical data including age, gender, ASA (American Soceity of Anesthesiologists' Physical Status Classification) and highest level of education.

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