The clinical team will not be blinded to group allocation as propofol, the most commonly used sedative, has a distinctive white appearance, which renders blinding unfeasible. Study participants will effectively be blinded, as the intervention will be initiated when the participant is still intubated and emerging from anaesthesia. Once weaned from mechanical ventilation, propofol is discontinued; however, DEX, a clear solution, will be one of a number of infusions, and it will be difficult for participants to distinguish/identify specific medications. Data collectors and those administering postoperative cognitive tests will be blinded and will not be able to ascertain group allocation during follow-up visits as they occur after discontinuation of the intervention.

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