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Human genome annotation files were downloaded from Ensembl FTP site. For hg19, gtf file was downloaded on August 23, 2017 from ftp://ftp.ensembl.org/pub/release-75/gtf/homo_sapiens /Homo_sapiens.GRCh37.75.gtf.gz. For hg38, gff3 file was downloaded from ftp://ftp.ensembl.org/pub/ release-97/gtf/homo_sapiens/Homo_sapiens.GRCh38.97.gtf.gz on September 22, 2019. The exon regions of major chromosomes (chr1-22, chrX, chrY, and chrM) were extracted and saved as BED files for both versions accordingly.

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