For each cross-sectional slice of each vessel on the FDG-PET/CT scans, mean and maximum SUV and TBR values will be calculated. The vessel with the highest average maximum TBR will be defined as the index vessel. The change from baseline in average maximum TBR in the index vessel will be analysed using analysis of covariance, estimating the treatment effect, and including the baseline value as a covariate. Point estimates and corresponding 95% CIs will be reported.

The sample size estimation for this study assumes a 15% change in TBR of FDG uptake, in keeping with the predicted change in LDL-C and effects on TBR seen in previous cholesterol-lowering studies.23 To achieve 90% power with a significance level of 5%, it is estimated that 30 subjects per group will be required.

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