The initial search strategy was developed by an experienced medical information specialist (EFG) in collaboration with the remainder of the review team. The search strategy will be finalised after peer-review by another experienced medical information specialist using the PRESS Peer Review of Electronic Search Strategies.39 Databases searched from inception will include PubMed (, Embase (, CINAHL (EBSCOhost), Scopus (, Dissertations & Theses Global (ProQuest), and the Cochrane Library (WileyOnline). A combination of keywords and subject headings will be adapted for use according to the specifications of each database. All records retrieved will include at least one antioxidant-related term and a term related to cancer therapies. Examples of antioxidant terms include but are not limited to vitamin C, lycopene and melatonin. Cancer therapy terms include but are not limited to chemotherapy, radiotherapy, antineoplastic and anticancer. The initial search strategy for Embase, which resulted in retrieval of more than 7000 records, is reported in online supplemental appendix 1. In addition to screening records retrieved from searching bibliographic databases, we will search the PROSPERO database of registered systematic reviews, scan the reference lists of included reviews and contact experts in the field to identify additional relevant systematic reviews.


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