FDG-PET/CT imaging of the aorta and carotid arteries will be performed at V2 and V7. The images will be analysed using OsiriX imaging software (Pixmeo, Bernex, Switzerland). The maximum standardised uptake value of FDG within each axial PET/CT fused image of artery, containing wall and lumen, will be divided by the average blood FDG concentration in the superior vena cava (for aorta) or jugular vein (for carotids) to yield an arterial maximum TBR, as a quantitative measure of arterial tracer uptake corrected for systemic uptake. Average TBR for ascending, descending and abdominal aorta, as well as average TBR for the right and left carotid arteries combined, will be calculated. Additional analysis will examine the proportion of aortic slices with a TBR of > 1.6, which is used as a threshold to define highly inflamed areas of aorta. Imaging data will be analysed blinded to the allocated study treatment and visit number.

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