The primary outcome will be the change in vascular inflammation on FDG-PET /CT using derivatives of standard uptake value and tissue to background ratio (TBR) in the aorta and carotid arteries of patients following approximately 8 weeks of treatment.

A variety of secondary outcome measures include comparison of the effects of adding alirocumab or ezetimibe on top of high-dose statin treatment on FMD and sublingual GTN response, as surrogate measures of endothelial-dependent and endothelial-independent vasodilation, respectively, changes in Aix, PWV, cIMT, lipid profile, hsCRP and other markers of systemic inflammation. An assessment of safety and tolerability will be undertaken as part of standard clinical practice, including physical examination, blood pressure, heart rate, 12-lead ECGs, clinical laboratory tests and adverse event reporting.

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