The areas of uncertainty concerning the use of antioxidant supplements during chemotherapy for cancer have been described above. We will answer the following research questions:

Among systematic reviews of RCTs on antioxidant supplements during chemotherapy, to what extent have research questions been posed regarding the effects of antioxidant supplementation on the therapeutic efficacy of chemotherapy?

What systematic review evidence exists regarding the use of antioxidant dietary supplements during chemotherapy with respect to:

(a) Whether supplementation with specific antioxidants promotes or attenuates the efficacy of chemotherapeutic treatment?

(b) Improvement of chemotherapy-related side effects and quality of life?

(c) Adverse clinical effects potentially associated with antioxidant supplementation?

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