We will conduct a detailed search on MEDLINE and EMBASE. Detailed searches will be conducted from the inception of the database until the date the searches are run (see online supplemental appendix 1). The search will include terms related to HRV, postsurgical pain, non-cardiac surgery and relevant cardiovascular outcomes (eg, myocardial infarction, pulmonary embolism). The bibliography of identified articles will be cross-referenced to check for additional studies to include in the review. The search strategy will be developed in consultation with a librarian specialising in literature searches.

bmjopen-2020-044949supp001.pdf

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