Catheter tip colonization was defined as a catheter tip with 15 or more colony-forming units [11]. The CRBSI definition adhered to the IDSA guidelines [12], which required the catheter tip to be colonized by a microorganism that was phenotypically the same as a microorganism isolated from a peripheral blood culture. A suspected CRBSI was identified when a patient developed a new episode of fever or sepsis [11], with at least 1 additional parameter described in the 2001 ISDC guidelines noted in the progress notes in the medical charts [13]. Fever was defined as a temperature > 38.3 °C[13]. Sepsis was defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, as in the Third International Consensus Definitions [6].

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