The lentivirus transfection and efficacy measurements were performed as previously described [26]. The lentivirus-based vectors for circATP5B overexpression, HOXB5 overexpression, SRSF1 overexpression, RNAi-mediated knockdown of circATP5B, HOXB5 and SRSF1, and their negative controls were all constructed by Gene-Chem (Shanghai, China). The miR-185-5p mimic, inhibitor, and negative controls were obtained from Thermo Fisher Scientific (Assay ID: MH12486 and MC12486; Thermo Fisher Scientific, Waltham, MA, USA). The sequences of all siRNAs are listed in Supplementary Table 2. The transfection efficacy was detected by qRT-PCR and western blotting.

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