As appropriate, summary data with continuous variables are presented as descriptive statistics, including n, mean ± standard deviation (SD), median/interquartile, and maximum/minimum, whereas the categorical variables are summarized using frequency and percentages. A mixed model (repeated measures) was used to analyze the outcomes from multiple follow-up times to compare the efficacies between the two groups, whereas comparisons within the same group were performed using the model-estimated contrasts. If the outcomes were highly skewed, a Wilcoxon signed rank sum test was used to make comparisons of each intragroup follow-up effect by covariance adjustment of the baseline. In addition, categorical variables were analyzed by Fisher’s exact tests. All data from this study were analyzed by SPSS 23.0 software (SPSS Inc., Chicago, IL, USA) or GraphPad software version 7.0 (CA, USA), as appropriate. Two-sided p < 0.05 was considered statistically significant.

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