Chi square and Fishers exact tests were used to compare dichotomous variables. Student’s t-tests were used to assess differences between parametric continuous variables in low and high-dose groups. Non-parametric continuous variables were evaluated with the Wilcoxon-Mann–Whitney test. All statistical analyses were performed using Stata, version 14.2 (StataCorp, College Station, TX).

Written informed consent was obtained on all patients. The present study was approved by the Johns Hopkins Institutional Review Board.

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