Inclusion criteria: (1) Enrolled cancer subjects were patients with diagnosis of malignancy according to International Classification of Diseases, Ninth Revision code (ICD-9). (2) Patients whose age < 18 were excluded. (3) The first ICU stay of the first hospitalization.

Suspected infection [20] was based on the International Classification of Diseases, Ninth Revision, Clinical Modification codes (ICD-9-CM). The diagnosis of sepsis was identified using the third international consensus definitions for sepsis and Septic Shock (Sepsis-3) [21]. The screening process of enrolled patients is shown in Fig. 1.

Flow plot of data extraction and filtration from the MIMIC-III database

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