This study is based on data from the Disease Analyzer database (IQVIA), which compiles drug prescriptions, diagnoses, and basic medical and demographic data obtained directly and anonymously from computer systems used in the practices of general practitioners (GPs) and specialists. Diagnoses (International Classification of Diseases, 10th Revision [ICD-10]), prescriptions (Anatomical Therapeutic Chemical [ATC] classification system), and the quality of reported data were monitored by IQVIA based on multiple criteria (e.g., completeness of documentation, linkage between diagnoses and prescriptions) [14]. In Germany, the sampling methods used for the selection of physicians’ practices were appropriate for obtaining a representative database of general and specialized practices [14]. Finally, this database had already been used in studies focusing on asthma [15] and drug utilization [16, 17].

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