Sensitivities, specificities, and accuracies for CTC and colonoscopies were defined as per Eqs. 1, 2, and 3:

where

TP: True positives: Detected by index test and detected by surgery/surgical pathology.

TN: True negatives: Not detected by index test and not detected by surgery/surgical pathology.

FP: False positives: Detected by index test but not detected by surgery/surgical pathology.

FN: False negatives: Not detected by index test but detected by surgery/surgical pathology.

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