TF foot-printing analysis was processed using ATAC-pipe. To analyse the footprint of each TF, ATAC-pipe function “--Footprint” scans TF-binding sites by invoking motif matrix with HOMER, filters out sites with CRP stimulation significant changes peak list to obtain the TF-binding sites, and counts for the per base Tn5 cleavage events around the centres of TF-binding sites (− 100 to 100 bp).

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