We first arranged the gene matrix of log2 fold change (CRPstim/control) in descending order and then use the R package GSEABase to calculate the enrichment score and p of the gene set downloaded from MSigDB [28] in the gene matrix. The values of p less than 0.05 are considered to be significantly enriched. “Proinflammatory gene set” and “regulation of OC Differentiation gene set” are available from MSigDB with ID GO:0050729 (https://www.gsea-msigdb.org/gsea/msigdb/cards/GO_POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE) and GO:0045670 (http://www.gsea-msigdb.org/gsea/msigdb/geneset_page.jsp?geneSetName=GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION).

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