StarBase bioinformatics prediction website ( was utilized to predict target mRNAs of miR-133a. miR-133a was found to be located on chromosome 18 at chr18:21825698–21825785 using the UCSC ( website. The correlation of KDM5C with miR-133a or PTBP1 was analyzed in TCGA-LUAD database ( The staining intensity of six genes, including PTPB1, SP1, ANXA5, DUSP1, LDLR and NME4, was analyzed in lung cancer or normal lung tissues via the HPA website ( Expression of PTP1B in a variety of cancer tissues and cells were analyzed by the CCLE database ( PTBP1 and KDM5C expression profiles were detected using the Oncomine database ( in Garber Lung,13 Hou Lung,14 Okayama Lung,15 Selamat Lung,16 Stearman Lung,16 and Talbot Lung.17

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