StarBase bioinformatics prediction website (http://starbase.sysu.edu.cn/) was utilized to predict target mRNAs of miR-133a. miR-133a was found to be located on chromosome 18 at chr18:21825698–21825785 using the UCSC (http://bio.lundberg.gu.se/courses/vt13/ucsc.html) website. The correlation of KDM5C with miR-133a or PTBP1 was analyzed in TCGA-LUAD database (https://cancergenome.nih.gov/). The staining intensity of six genes, including PTPB1, SP1, ANXA5, DUSP1, LDLR and NME4, was analyzed in lung cancer or normal lung tissues via the HPA website (https://www.proteinatlas.org/). Expression of PTP1B in a variety of cancer tissues and cells were analyzed by the CCLE database (https://portals.broadinstitute.org/ccle/about). PTBP1 and KDM5C expression profiles were detected using the Oncomine database (https://www.oncomine.org/) in Garber Lung,13 Hou Lung,14 Okayama Lung,15 Selamat Lung,16 Stearman Lung,16 and Talbot Lung.17

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