With overlapping genes as the bond, pairs of active component–targets were constructed. Then, these pairs were imported into CytoScape to construct an XYS–IS interaction network. In this network, the nodes represent herb components and target proteins; the edges represent the interaction between herb components and target genes. The “network analyzer” plugin was used to analyze the network structure, calculate network parameters (eg, degree and betweenness centrality) to analyze preliminarily the main active components in XYS and their main targets.

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