The structural formulae of potentially active compounds in XYS that we obtained were uploaded to PharmMapper. The targets of these compounds were obtained by reverse docking. SwissTargetPrediction was used to supplement the targets of the compounds. All docking results were combined, and repeated targets were deleted to obtain a database for XYS targets. The protein targets related to IS treatment were searched in OMIM, GeneCards, DisGeNET, TTD, and DrugBank using the keywords “IS”, “ischemic stroke”, “stroke” and “cerebral ischemic stroke”. Simultaneously, the targets of IS were supplemented by combining literature retrieval and data mining. All retrieval results were combined and repeated targets were deleted to obtain the target database for IS.

Upon intersection of the databases for XYS targets and IS, the obtained targets were deemed to be the overlapping genes of XYS-IS. The UniProt was used to determine the standard names of these overlapping genes.

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