With regard to network pharmacology, the databases that we used were: Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP; http://lsp.nwu.edu.cn/tcmsp.php/); TCM-Datebase@Taiwan database (TCMD; http://tcm.cmu.edu.tw/), PubChem Compound database (www.ncbi.nlm.nih.gov/pccompound/), Chemical Book (www.chemicalbook.com/); PharmMapper (http://lilab.ecust.edu.cn/pharmmapper/index.php/); SwissTargetPrediction (www.swisstargetprediction.ch/); DrugBank (www.drugbank.ca/), Online Mendelian Inheritance in Man (OMIM; www.omim.org/), GeneCards (www.genecards.org/), DisGeNET (http://www.disgenet.org/web/disGeNET/menu/); Treatment Targets Database (TTD; http://bidd.nus.edu.sg/); Protein Database (PDB; www.rcsb.org/), UniProt (www.rcsb.org/) and Search Tool for the Retrieval of Interacting Genes/Proteins (STRING; https://string-db.org/).

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