In this review, our main aim was to identify potential biomarkers in the morphology of the LC that were associated with, and indicative of, certain pathologies. Therefore, we have opted to only report those that performed a statistical comparison between an experimental and a control group. The extracted data for each paper consist of the LC structural parameters, their mean and standard deviation (SD), and the p values of the statistical analysis performed between experimental and control groups. Moreover, the image processing methodology applied to compute each feature was taken into account for posterior comparisons.

For all the included articles, the following characteristics are obtained and presented in Table 1: sample size, including the number of patients and eyes per group; age and statistical comparison (p value) between control and experimental groups; OCT device model, manufacturer, and light-source wavelength; cutoff value for the signal strength index (SSI) or similar qualitative image criteria used to exclude patients/eyes; and field of view of the OCT image [17]. Moreover, the procedures followed to measure the LC features, and their respective values, were also collected and compiled.

Characteristics of the reviewed studies.

LC = lamina cribrosa, LCT = lamina cribrosa thickness, cLCT = central lamina cribrosa thickness, LCD = lamina cribrosa depth, cLCSD = central anterior lamina cribrosa surface depth, PTT =  prelaminar tissue thickness, cPTT = central prelaminar tissue thickness, Exp = experimental, YG = young group, MG = middle group, OG = old group, EDI = enhanced depth imaging, SD = spectral domain, SS = swept source, ALCSD = anterior lamina cribrosa surface depth, ONH = optic nerve head, PPA = peripapillary atrophy, LCCI = lamina cribrosa curvature index, PLD = posterior laminar depth, and NA = not available, that is, not mentioned in the article.

Data collection comprehended all structural components related to the LC and the surrounding ONH region that were included on the OCT B-scan images. Several locations, planes (superior, middle, and inferior), and sectors were considered for the measurements. The sectors were defined according to the Garway-Heath map [71]. The approach of data extraction by one investigator (ASP) with further verification by a senior author (JBB) has been used, as this has been demonstrated to be as accurate as double independent data extraction [72].

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