The participants will undergo 40 sessions with 24-style Tai Chi. The exercise of Tai Chi will be performed four times a week (Monday, Tuesday, Thursday, and Friday) and will last for 10 weeks [15]. Each exercise session lasts for an hour, including 10-minute warm-up, 40-minute Tai Chi exercise, and 10-minute relaxation.

Before the formal intervention, participants were involved in motor learning and strength training under the guidance of two professional Tai Chi instructors. During the intervention, they exercise strictly under the 24-style Tai Chi exercise standard operating procedure (SOP), which was formulated by two Tai Chi experts. In each session of the exercise, the instant heart rate will be counted both at the pre- and posttrial, and the sports self-rating scale will also be filled out. Participants who did not come will be recorded. The training will be considered effective when the rating of perceived exertion (RPE) of the subjects reaches 4–6 levels in each session, and training times must not be less than 80% (32 times) of total training times.

During the treatment period, participants are usually not recommended to use concomitant care or interventions. However, if required (such as, aggravation of the patient's condition), participants will be permitted to use extra osmotic laxatives. The type and dosage of medication used should be recorded in the case report forms (CRFs).

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