Patients who match the inclusion criteria will be recruited. FC patients will be diagnosed by two gastroenterologists in the digestion department of the Hospital of CDUTCM, according to the Rome IV Diagnostic Criteria for FC [14]. Each FC patient will undergo a careful physical examination including a routine blood test, routine urine test, routine stool test, blood biochemical test (ALT, AST, BUN, Scr), transabdominal ultrasound, and dynamic electrocardiogram. The inclusion criteria and exclusion criteria of FC patients were as same as our previous study [15].

Patients will be included in the study if they (1) reach the Rome IV Diagnostic Criteria for FC [14], (2) are right-handers and the age range is between 18 and 35, (3) have less than three CSBMs every week, (4) the Cleveland Constipation Score (CCS) score >10, and (5) provide a written informed consent form.

Patients will be excluded from the study if they (1) are pregnant women, or plan to be pregnant within 3 months, or are breast-feeding women, (2) are incapable of sports, (3) have a history of head trauma and loss of consciousness, (4) have diabetes or serious cardiovascular, neurological, psychiatric, renal, or respiratory disease, (5) have moderate or serious depression and anxiety, (6) cannot keep silent for 20 minutes while lying down, (7) have any contraindications to fMRI scanning including the presence of metal stent, metal denture, or claustrophobia, (8) have taken other exercises (including meditation and yoga) that may improve constipation over 30 minutes every week in the last 3 months, (9) have taken gastrointestinal motility medicine, nonsteroidal anti-inflammatory medicine, and steroids in the last 15 days, (10) have received other treatments (including surgery, diet modification, biofeedback, or probiotics) in the last month, or (11) have participated in any other clinical trials in the past 3 months.

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