The studies were considered eligible according to the PICOS criteria: (1) participants (P): all adults who received colonoscopy; (2) interventions (I) and comparisons (C): comparison of 1L PEG-AA versus 2L PEG-A before colonoscopy; (3) outcome (O): the primary outcome involves the bowel preparation efficacy as measured by Boston Bowel Preparation Scale (BBPS), and the secondary outcomes include the tolerability and complications associated with the regimen; and (4) study (S): randomized controlled trials (RCTs).

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