Systematic searches were performed by two independent reviewers (Xin Yuan and Zhixin Zhang) through PubMed/MEDLINE, EMBASE, Cochrane Library, and Web of Science (up to March 10, 2020) with predefined search terms. The search strategy (example of EMBASE in Table S1) was formulated according to the Medical Subject Heading/entrée along with the keywords relating to “colonoscopy,” “polyethylene glycols,” and “1L.” Only full texts published in English were included.

After removing the duplicate studies by the embedded function in the EndNote software, the titles and abstracts were screened, and then, the full texts of the potentially relevant studies were reviewed against the criteria. To avoid the literature omission, we also looked at the references of each literature.

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