Clinical, laboratorial, and hemodynamic data were extracted using a dedicated software. All patients underwent a candidacy right heart catheterization (RHC) with a Swan-Ganz catheter via the femoral vein before sildenafil initiation; the group of patients that were exposed to sildenafil underwent a second RHC to assess the hemodynamic effect of the drug. After HT, right ventricular systolic and end-diastolic pressures were registered during the first endomyocardial biopsy, which was performed at 1 week after HT. A late hemodynamic follow-up was collected during the predefined RHC at 1 year after HT in both groups.

Cardiac output (CO) was measured by the Fick method, and cardiac index (CI) was calculated by dividing the CO by the body surface area. PCWP, sPAP, dPAP, and mPAP were measured automatically. PVR and TGP were calculated using the following formulas: TPG (mmHg) = mPAP - PCWP; PVR (WU) = TGP/CO.18 A follow-up was conducted for a median of 6.9 years (range 4.2 – 6.9 years) by personal interview in the outpatient ward, through a review of hospital registries, and by telephone contact, and was obtained for every patient included in this study. Confidentiality was always respected.

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