The experimental protocol was approved by Institutional Ethical Committee of Jiangxi Provincial People’s Hospital, with ethic number: 202005088779C09. Wistar albino rats (200–250g) were used for this study and the animals were kept in the standardized laboratory facilities. The kits for estimating the levels of creatine kinase (CK-MB), cardiac troponin T (cTnT), HIF-1α and Nrf-2 were procured from MyBioSource, Inc., San Diego, CA, USA.

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