Thirty-four patients from the Cystic Fibrosis Resource and Competence Center (CFRCC) of the Grenoble-Alpes University Hospital (CHUGA) were recruited retrospectively according to the following inclusion criteria: diagnosis of CF according to the national guidelines, 16 years old in 2010, chronically infected by P.a according to the EuroCareCF reference criteria [55], 3 P.a isolates sampled over a 3 years follow-up period. The data are derived from clinical research on cystic fibrosis patient and bacterial samples named METAPYO: “A metabolomic approach for the study of the adaptive evolution of Pseudomonas aeruginosa during chronic pulmonary infections in cystic fibrosis”. This research was approved by the CHUGA institutional review board and authorized after its filing with the CNIL according to the french procedure for a monocentric retrospective study (Reference Methodology MR004-Compliance Commitment No. 2205066 v 0). Duly informed patients did not object to the conduct of the research.

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