To measure the degree of variability or heterogeneity in the effects of the intervention between the different studies, the I2 statistic (% of the variability of SMD attributable to heterogeneity and not to chance) was used, and the chi-square test was used to assess its statistical significance. It was assessed by visual examination of the forest plot and the chi-square statistic. The I2 was interpreted as absent (0%), low (25%), moderate (50%), or high heterogeneity (≥75%) [14]. The chi-square test was used to assess whether the differences observed between the studies were compatible with simple hazard [9].

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