All identified hits of pharmacophore-based virtual screening were sorted according to their pharmacophore-fit score, and 100 compounds were selected and filter on the basis of two rules, named rule of five and the Veber rule. Then the top 15 compounds were selected. These compounds were docked with the receptor and evaluated for binding energies and protein–ligand interactions by using AutoDock Vina. Pymol was used for making complex files of receptor and ligand, and for finding interactions, LigPlot was used, respectively.

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