Eight medical cannabis users (Users) and eight sex- and age-matched controls (Non-Users) were recruited (subject demographics are listed in Table 1). Inclusion criteria included (1) being between the ages of 50 and 80 years old, (2) healthy enough to complete the protocol based on information obtained from a clinical exam and past medical history, (3) part of the Iowa Medical Cannabidiol program (user group) or have not used cannabis in the last five years (Non-User group), (4) able to comprehend the protocol, as indicated by the ability to respond to questions about the study after reading the consent form, (5) able to use and be contacted by telephone, and (6) able to speak, read, and understand English and complete a questionnaire in English. Exclusion criteria included (1) pregnancy, (2) history of traumatic brain injury, and (3) other drug use or alchoholism. This study was approved by the Institutional Review Board at the University of Iowa (IRB#201909808, 17 December 2019), performed in accordance with the Declaration of Helsinki, and all subjects provided written consent before participating.

Subject demographic information stratified by user status. Data are mean ± SD.

THC = Δ-9-Tetrahydrocannabinol, CBD = cannabidiol, PD = Parkinson’s disease.

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