In subgroup analyses, we analyzed whether predictive performance and detected features differed between subsets of patients. Due to the small sample size, these exploratory subgroup analyses were performed on the combined training and test data sets. We investigated the performance in presymptomatic PLN p.Arg14del mutation carriers. Presymptomatic was defined as follows: no cardiac symptoms as per judgment of the treating physician, no history of (non)sustained ventricular arrhythmia, premature ventricular complex burden of <500 beats per 24 hours and left ventricular ejection fraction ≥45%.

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