Adults age 18 or older with histologically or cytologically documented relapsed and/or refractory AML were eligible for the study. They were required to have relapsed/refractory disease and be ineligible for, declined, or have failed at least one previous salvage regimen. Notably, patients were excluded if they had active central nervous system (CNS) disease, poor performance status (ECOG greater than or equal to 3), or persistent grade 3 or higher prior vincristine related neuropathy.

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