All statistical analyses were performed by SPSS 24.0. Data were analyzed using descriptive methods, including mean ± SD, median, interquartile range (IQR) and proportions. The Student’s t-test was used to analyze differences for continuous, normally distributed data; and continuous, non-normally distributed data were analyzed with the Mann–Whitney test. Chi-square or Fisher’s exact tests, as appropriate, was used to process categorical variables. It was considered statistically significant when a P-value was less than 0.05.

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