Definitions used for maternal glycaemic control for each period were: hypoglycaemia, < 3.5 mmol/L; elevated fasting BGC, ≥ 5.5 mmol/L; hyperglycaemia, BGC above a threshold of 7, 8, 10 or 11 mmol/L; peak hyperglycaemia, maximum BGC; time to onset of hyperglycaemia, time between administration of the first dose of ANC and the first BGC above the threshold; time to resolution of hyperglycaemia, the time from the first dose of ANC to the last hyperglycaemic recording, and blood glucose measurements out of glycaemic target range, < 4.0 mmol/L or > 7.0 mmol/L.

Definitions used for neonatal glycaemic control were: neonatal hypoglycaemia, < 2.6 mmol/L; severe hypoglycaemia, ≤ 2.0 mmol/L [22]; recurrent hypoglycaemia, a second or subsequent BGC of ≤ 2.6 mmol/L occurring after resolution of a previous episode of hypoglycaemia (defined as at least one BGC of > 2.6 mmol/L); hyperglycaemia, > 8.0 mmol/L [23].

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