At enrollment, all patients underwent comprehensive physical examinations, including assessment of clinical symptoms of malaria and neurological examinations. Microscopic examinations of thick and thin blood smears confirmed the presence of Plasmodium species and its corresponding load. Adverse drug reactions were monitored and recorded. If vomiting occurred within 1 hour of taking the drug, the drug was readministered. Patients were hospitalized for 7 days or until malaria symptoms disappeared or the parasites cleared. All patients were followed up weekly from the start of treatment to the 28th day. If any discomfort occurred during the follow-up, patients could return to the hospital for additional follow-up.

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