The local research team collected information on the clinical, radiological, and laboratory evolution of the patients using standardized forms, from the clinical-laboratory area and the economic area of the Brazilian Tuberculosis Research Network [Rede Brasileira de Pesquisa em Tuberculose - REDE TB], adapted and used in PROVE IT. The statistical package IBM®SPSS for Windows version 20.0 was used for statistical analysis.

The analyses of this study were carried out with the results of the clinical trial 10 : the proportion of patients who received empirical treatment who underwent DST-MGIT (97.7%) and Xpert (45%); the average time between screening and receiving the result of the intervention test by the doctor at DST-MGIT (73 days) and at Xpert (9.10 days); the average time between screening and the beginning of the correct treatment by DST-MGIT (57.7 days) and Xpert (26.8 days). A total of 53 patients were included in the DST-MGIT (n= 36) and Xpert (n= 17), as a criterion of effectiveness: negative sputum result after the sixth month of follow-up (n = 20), of patients who underwent DST-MGIT; negative sputum result after the sixth month of treatment (n = 10), of patients who underwent Xpert; favorable clinical and radiological results of patients who did not have sputum after the sixth month of follow-up of those who underwent DST-MGIT (n = 9) and those who underwent Xpert (n = 6) at the beginning of treatment.

The follow-up of patients was performed by smear, culture, and DST-MGIT. Xpert was not performed in the follow-up to avoid false positive results.

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