Dead space and alveolar ventilation calculations
This protocol is extracted from research article:
Physiological dead space and alveolar ventilation in ventilated infants
Pediatr Res, Feb 18, 2021; DOI: 10.1038/s41390-021-01388-8

The dead space was calculated from the Enghoff modification of the Bohr equation by substituting the partial pressure of alveolar carbon dioxide (PACO2) with arterial partial pressure (PaCO2).14 The physiological dead space (VDphys) (ml) was calculated from the following equation:

The anatomical dead space (VDana) (ml) was calculated from the following equation:

The alveolar dead space (VDalv) (ml) was calculated from the following:

where Vte is the expired tidal volume in ml, PaCO2 is the partial pressure of CO2 in the blood in mmHg, PEtCO2 is the maximal end-tidal CO2 in mmHg, and PemeanCO2 is the mean CO2 of the mixed expired air (mmHg).15

Minute and alveolar ventilation were also calculated:

where Vte is the expired tidal volume in ml/kg, VDphys is the physiological dead space in ml/kg and frequency is the respiratory rate in breaths per minute.

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