Study design and participants
This protocol is extracted from research article:
Physiological dead space and alveolar ventilation in ventilated infants
Pediatr Res, Feb 18, 2021; DOI: 10.1038/s41390-021-01388-8

A prospective study of ventilated infants at King’s College Hospital NHS Foundation Trust neonatal intensive care unit was undertaken. Infants were recruited from 1 January 2019–1 September 2020 after written informed parental consent was obtained. Approval was given by the London Camden and King’s Cross Research Ethics Committee (REC reference: 18/LO/1602).

Term and preterm infants were eligible for recruitment into the study if they were receiving invasive mechanical ventilation, but did not have major congenital or chromosomal abnormalities. Infants were supported by volume-targeted or pressure-controlled time-cycled ventilation using the SLE6000 neonatal ventilator (SLE, Croydon UK). Infants were intubated, as per unit policy, with shouldered Cole’s endotracheal tubes (ETT).12 All preterm infants who required intubation and ventilation received surfactant.

Term born infants with no underlying respiratory disease who required invasive mechanical ventilatory support for poor perinatal adaptation (term controls), preterm infants with acute RDS, and preterm infants supported by invasive ventilation for longer than 1 week who were classified as having evolving9 or established BPD were recruited.

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