All imaging data were obtained on a 3-Tesla Trio MRI system (Siemens Healthcare, Erlangen, Germany) equipped with a 12-channel phase-array head coil. DTI images were acquired by a single-shot echo planar imaging (EPI) sequence with the following parameters: repetition time (TR) = 10,000 ms; echo time (TE) = 92 ms; flip angle = 90°; field of view (FOV) = 256 mm × 256 mm; matrix = 128 × 128; slice thickness = 2 mm, no gap; 75 axial slices; 64 encoding diffusion directions with b = 1,000 s/mm2; and 1 non-diffusion b = 0 s/mm2 images. The 3D high-resolution structural images were obtained using a T1-weighted magnetization prepared rapid acquisition gradient echo (MPRAGE) sequence, as follows: TR = 1,900 ms, TE = 2.52 ms, TI = 900 ms, flip angle (FA) = 9, matrix = 256 × 256, thickness = 1.0 mm, 176 slices with voxel size =1 × 1 × 1 mm. Then, all the subjects were required to undergo conventional brain T1-weighted and fluid attenuated inversion recovery (FLAIR) images to exclude organic diseases and white matter (WM) hyperintense lesions.

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