Data were shown as the mean ± standard deviation (SD) and statistical analysis was performed by SPSS 24.0. Survival curves were produced by Kaplan-Meier plot and analyzed by log-rank test. Difference analysis was performed using Student’s t test for two groups and one-way analysis of variance (ANOVA) followed by Tukey’s test for multiple groups. P < 0.05 was deemed as significant difference.

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