All hospitals belonging to the GIRCG are eligible to participate in the ADiGe Trial, irrespective of their hospital volume. A total of 9 centers applied to participate, and, at the time of this publication, the study has already been approved by the local IRB of each center (Verona University Hospital, the leading Center, Orbassano Hospital of Turin, San Raffaele Hospital of Milan, Morgagni Hospital of Forlì, Federico II University Hospital of Naples, Niguarda Hospital of Milan, S. Orsola-Malpighi Hospital of Bologna, Parma University Hospital, Modena University Hospital).

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