SPSS 22.0 statistical software (IBM Corp. Armonk, NY, USA) was applied for statistical analysis. All data were expressed as the mean ± standard deviation. Data between LAD and paracancerous tissues were compared by paired t-test, while data between the other two groups of unpaired design were analyzed using unpaired t-test. Data comparison among multiple groups was conducted using one-way analysis of variance (ANOVA) and Tukey’s post-test. Cell viability at different time points was compared using two-factor ANOVA, and tumor volume data at different time points were compared using Bonferroni-corrected repeated measures ANOVA. Pearson correlation or Spearman correlation was employed to analyze the correlation between HOXA10 and HDAC1. p < 0.05 was considered to be indicative of statistically significant difference.

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