The RNA-Seq data and clinical information of male GC patients were obtained from TCGA database (https://tcga-data.nci.nih.gov/tcga/). A total of 2498 IRGs were obtained from the Immunology Database and Analysis Portal (ImmPort) database (https://www.immport.org/home) [17]. We also downloaded gene expression profiles and clinical data of GSE15460 from GEO (http://www.ncbi.nlm.nih.gov/geo/) for validation dataset.

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