Statistical analysis

Descriptive statistics of the clinical parameters were assessed before and during MC treatment. Additionally, the dosages of milled MC, THC, and THC + CBD in the sachets and oil drops were measured. All demographic data were reported as median and interquartile range (IQR) and mean and standard deviation (SD).

For statistical analysis, Wilcoxon signed-rank tests for paired data were used to compare the parameters (NRS, ODI, HADS, WPI, and SyS) before cannabis therapy and after 1, 3, and 12 months of MC therapy. The data are from per protocol analyses. Results with P values < 0.01 were considered significant. No calculation of required sample size was done because it was a post hoc study. IBM SPSS software, version 25.0, was used for the statistical analysis.

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